Lior Pachter
Department of Mathematics, Molecular & Cell Biology and Electrical Engineering & Computer Science
University of California, Berkeley, United States



Presentation Title: Sequencing based functional genomics (analysis)

Presentation Time: Monday, July 22, 9:00 AM - 10:00 AM

Room: Hall 1



Sequence census methods couple high-throughput DNA sequencing to biochemical assays and are transforming standard functional genomics assays into powerful genome-wide probes of biochemical activity. We will survey the plethora of *-Seq assays that have been developed and describe examples of how computational advances are going hand-in-hand with the biotechnology to enable biological discovery.


I am a computational biologist working in genomics. My career began in comparative genomics, and initially I was interested in genome alignment, annotation, and the determination of conserved regions using phylogenetic methods. I contributed to the mouse, rat, chicken and fly genome sequencing consortia, and the ENCODE project. More recently I've become focused on functional genomics, which includes answering questions about the function and interaction of DNA, RNA and protein products. I'm particularly interested in applications of high-throughput sequencing to RNA biology.

I'm also interested in algorithms, statistical methodology, and mathematical foundations for computational genomics. These interests are reflected in my appointments across different departments and colleges: Mathematics, Molecular & Cell Biology, and Electrical Engineering & Computer Science. My group includes students and postdocs from Computer Science, Mathematics, Bioengineering, Molecular and Cell Biology and Statistics.