T03 - IMGT, the Global Reference in Immunogenetics and Immunoinformatics

Date: Sunday September 7, 2014 (9h-13h) 

Venue: "Palais de la Musique et des Congrès", Place de Bordeaux,  67082 Strasbourg (see location on google map).

Short description:

IMGT¬ģ, the international ImMunoGeneTics information system¬ģ (http://www.imgt.org) was created in 1989 by the Laboratoire d'ImmunoG√©n√©tique Mol√©culaire (LIGM) of the Professors Marie-Paule Lefranc and G√©rard Lefranc (University Montpellier 2 and CNRS) at Montpellier, France. IMGT¬ģ is the global reference in immunogenetics and immunoinformatics and is the first and, up to now, the only integrated information system in immunogenetics and immunoinformatics.

The aim of the tutorial is to familiarise biologists, bioinformaticians and computer scientists involved in immunogenetics and immunoinformatics research projects with the IMGT unique approach which bridges the gap from genes to 3D structures for immunoglobulin and T cell receptor repertoire analysis from fishes to humans, and for antibody engineering and humanization.

This tutorial will start with an overview of the IMGT¬ģ system built on the IMGT-ONTOLOGY axioms and concepts, and of its major databases.¬† The main topics¬†will be presented from sequences to structures and exemplified with IMGT/V-QUEST and IMGT/JunctionAnalysis for the analysis of nucleotide sequences and the high-throughput version IMGT/HighV-QUEST for next generation sequencing (NGS), IMGT/DomainGapAlign for amino acid sequences, IMGT/3Dstructure-DB for 3D structures, contact analysis and paratope/epitope interactions, and the IMGT/mAb-DB interface with access to therapeutical antibodies data.

 

Name of the chairs: Véronique Giudicelli & Patrice Duroux

Contact e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

Note: bring your on laptop

 

Intended audience and possible prerequisites:

Biologists, bioinformaticians and computer scientists involved in immunogenetics and immunoinformatics of the adaptive immune response or in antibody engineering and humanization.

 

Presenters:

Marie-Paule Lefranc, IMGT founder and director, CNRS, Université Montpellier 2

Véronique Giudicelli, PhD, IMGT Bioinformatics manager, CNRS, Université Montpellier 2 

Patrice Duroux, PhD, IMGT Informatics manager, CNRS

Souphatta Sasorith, PhD, IMGT Postdoc, CNRS, Université Montpellier 2

 

References:

Lefranc, M.-P., Giudicelli, V., Ginestoux, C., Jabado-Michaloud, J., Folch, G., Bellahcene, F., Wu, Y., Gemrot, E., Brochet, X., Lane, J., Regnier, L., Ehrenmann, F., Lefranc, G. and Duroux, P.
IMGT¬ģ, the international ImMunoGeneTics information system¬ģ
Nucl. Acids Res. 37, D1006-D1012 (2009). doi:10.1093/nar/gkn838. PMID: 18978023

Giudicelli, V. and Lefranc, M.-P.
IMGT-ONTOLOGY 2012
Frontiers in Bioinformatics and Computational Biology Online access. Front. Genet. 3:79 (2012). Epub 2012 May 23. PMID: 22654892

Lefranc M-P.
Immunoglobulin (IG) and T cell receptor genes (TR): IMGT¬ģ and the birth and rise of immunoinformatics.
Front. Immunol.  Feb 05;5:22 (2014). doi: 10.3389/fimmu.2014.00022. Open access.

Cold Spring Harb Protoc. 2011 Jun 1;2011(6). pii: pdb.ip86: pages 595-761.
IMGT booklet  (pdf available in IMGT references  'With generous provision from Cold Spring Harbor (CSH) Protocols').

 

 

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